AMMONIA

Code
900.0375
Name
AMMONIA
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
NH3
CPT Codes
82140
Site
SBMF
Reference Test
29038
ATLAS Test Code

AMMONIA SBMF

Specimen Information

Type

Lavender, plasma *IF NEEDED STAT, PLEASE CONTACT LAB BEFORE DRAWING PATIENT*

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer plasma to separate plastic tube Frozen CRITICAL FROZEN – Separate specimens must be submitted when multiple tests are ordered

Fasting Required?
False
Patient Instructions

Tube must be at least 3/4 full. After collection, immediately place tube in ice slush (ice and water mixture). Deliver tube to laboratory within 30 minutes of collection time for centrifugation. Plasma must be removed from cells within 30 minutes of collection time

Reference Range

See Report Critical High: 70 µmol/L or greater

Methodology

Enzymatic

Clinical Significance

Useful in the diagnosis and prognosis of Reye’s syndrome. The bulk of ammonia in the body is generated in the gastrointestinal system by action of bacterial enzymes on the contents of the colon and from hydrolysis of glutamine. It is removed in the liver and converted to urea through a series of enzymatic reactions in the Krebs-Henseleit cycle. Among other conditions, advanced liver disease and hepatic encephalopathy result in elevated levels of ammonia in blood. The determination of ammonia is very useful in the diagnosis and prognosis of Reye’s syndrome. Elevated blood ammonia exerts toxic effects on the central nervous system.

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