HEPATITIS B SURFACE AB QUANT

Code
800.8312
Name
HEPATITIS B SURFACE AB QUANT
Category
None
Department
Serology
Start Date
Expiration Date
Synonyms
Anti-HBs Ab; HBsAB
CPT Codes
86706
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated
48 Hour stability

Fasting Required?
False
Patient Instructions

Reference Range

See report

Methodology

Chemiluminescence

Clinical Significance

Presence of hepatitis B surface antibody indicates previous hepatitis B infection or previous administration of hepatitis vaccine (Heptavax-B).

Hepatitis B virus (HBV) is the sole human pathogen in the family of hepatitis-associated DNA viruses, and is found worldwide. Distribution of HBV infection will vary among geographical areas and population groups. Transmission of the virus is due to parenteral contact, through the exchange of blood or blood products, sexual contact, and perinatal spread from mother to newborn. Clinical manifestations range from mild asymptomatic infections to severe fulminant hepatitis. Over 90% of infected adults will have an acute self-limiting infection, with jaundice and abnormal liver function. Recovery occurs without any chronic sequelae. Availability of recombinant HBV vaccines, and the recommendation of universal immunization for infants and other high-risk persons has aided in the prevention of HBV infections. In addition, treatment with alpha-interferon to relieve symptoms is available. Results have shown positive response to treatment in 40-50% of selected individuals with chronic active hepatitis B. Classification of a hepatitis B infection requires the identification of several serological markers expressed during three phases (incubation, acute and convalescent) of the infection. The first marker to appear during the incubation phase is HbsAg, and indicates an ongoing infection with HBV. Antibodies to HbsAg generally appear after HbsAg has been cleared from the blood stream, usually 6 months after infection, and its presence represents recovery and immunity. However, in a few patients known to have antibodies to HgsAg, subclinical infections have developed. The presence of HgsAg antibodies should not be used as the sole marker in determining a prior hepatitis B infection.

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