HEPATITIS DELTA VIRUS ANTIBODY

Code
000.0000
Name
HEPATITIS DELTA VIRUS ANTIBODY
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Anti-HDV; HDV Ab
CPT Codes
86692
Site
SBMF
Reference Test
44205
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Frozen

Fasting Required?
False
Patient Instructions

Reference Range

Negative

Methodology

Enzyme Immunoassay (EIA)

Clinical Significance

Diagnosis of HDV. Always seen in association with hepatitis B virus infection.

Infection with the hepatitis delta virus (hepatitis delta-agent, HDV) is always seen in association with hepatitis B virus (HBV) infection, where it may occur as a simultaneous acute infection or as an acute super-infection superimposed upon a case of chronic HBV hepatitis. This is an RNA virus that requires the presence of HBV for viral replication to occur. The serologic diagnosis of HDV depends upon the finding of HDV antigen and/ or the presence of anti-HDV. Patients will almost invariably have detectable hepatitis B surface antigen (HBsAg) and/or antibodies to hepatitis core antigen (anti- HBc) and hepatitis Be antigen (HBeAg). In patients with acute co-infections, hepatitis D antigen (HDVAg) appears early after HBsAg does and disappears with convalescence. Acute HDV infections are associated with anti-HDV IgM antibody and chronic cases usually only demonstrate IgG antibody. Both antibodies may eventually disappear following convalescence. The simultaneous assessment of anti-HBc IgM will help to differentiate co-infections (present) from super-infections (absent).

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