Amphetamines, Quantitative, Urine

Code
900.0020
Name
Amphetamines, Quantitative, Urine
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Amphetamine; Methamphetamine; Speed; Ice; Crank
CPT Codes
82145
Site
SBMF
Reference Test
47156
ATLAS Test Code

Specimen Information

Type

Urine, random

Volume

1.0 ml

Transport Info

Room Temperature. Refrigerated acceptable.

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Clinical Significance

Confirm positive screen results by an alternate, specific method; detect use. Amphetamines and amphetamine derivatives are classified as sympathomimetic amines with CNS stimulant activity. They have been classified as a Schedule II drug in the U.S. since 1969, and currently may be prescribed to treat narcolepsy, obesity and childhood deficit attention disorders. Amphetamines can be taken orally, injected intravenously, smoked, or snorted. They are psychologically and physiologically addicting; their effects include excitement, alertness, euphoria, decreased appetite, and reduced sense of fatigue. Side effects at low doses include irritability, anxiety, insomnia, blurred vision, increased blood pressure, and heart palpitations. Chronic, high dose users may develop a psychosis that can be indistinguishable from acute schizophrenia. Amphetamines are rapidly absorbed from the gastrointestinal tract and widely distributed through the body. Approximately 70% of a dose is eliminated in urine in the first 24 hours after administration, and depending on urinary pH, about 30% of the dose is excreted unchanged and the remainder as metabolites. Amphetamines may remain detectable in urine for 3-4 days after administration. Positive result indicates exposure to drug and does not necessarily indicate impairment.

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