HETEROPHILE AB BY LATEX AGGLUT REFLEX TO TITER

Code
900.1721
Name
HETEROPHILE AB BY LATEX AGGLUT REFLEX TO TITER
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
86308 If reflexed add 86309
Site
SBMF
Reference Test
28016
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated 48 hours

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

Qualitative Latex Agglutination; Semi-Quantitative Latex Agglutination

Clinical Significance

Use:
Initial serologic test to detect acute Epstein-Barr virus infectious mononucleosis.

Clinical Significance:
Heterophile antibody has been rarely associated with disease states other than infectious mononucleosis, such as leukemia, cytomegalovirus, Burkitt's lymphoma, rheumatoid arthritis, and viral hepatitis. A single heterophile antibody titer is considered to have no relation to the severity of the disease, but sequential titer determinations may be useful in following the course of an individual patient. Although most patients (90%) will have a detectable heterophile level within three weeks of infection, occasionally a patient with strong clinical signs of infectious mononucleosis may take as long as three months to develop a detectable level. The heterophile test or mononucleosis slide test is probably the best test for detecting acute Epstein-Barr virus (EBV) infection. Negative results are more common in children. If further testing is desired, collect additional specimens and retest every few days. EBV infection can also be established, especially in "monospot-negative" cases, with the use of EBV IgM-specific serologies.

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