HETEROPHILE AB BY LATEX AGGLUT REFLEX TO TITER
- HETEROPHILE AB BY LATEX AGGLUT REFLEX TO TITER
- Start Date
- Expiration Date
- CPT Codes
- 86308 If reflexed add 86309
- Reference Test
- Transport Info
Refrigerated 48 hours
- Fasting Required?
- Patient Instructions
- Reference Range
Qualitative Latex Agglutination; Semi-Quantitative Latex Agglutination
Initial serologic test to detect acute Epstein-Barr virus infectious mononucleosis.
Heterophile antibody has been rarely associated with disease states other than infectious mononucleosis, such as leukemia, cytomegalovirus, Burkitt's lymphoma, rheumatoid arthritis, and viral hepatitis. A single heterophile antibody titer is considered to have no relation to the severity of the disease, but sequential titer determinations may be useful in following the course of an individual patient. Although most patients (90%) will have a detectable heterophile level within three weeks of infection, occasionally a patient with strong clinical signs of infectious mononucleosis may take as long as three months to develop a detectable level. The heterophile test or mononucleosis slide test is probably the best test for detecting acute Epstein-Barr virus (EBV) infection. Negative results are more common in children. If further testing is desired, collect additional specimens and retest every few days. EBV infection can also be established, especially in "monospot-negative" cases, with the use of EBV IgM-specific serologies.