IMMUNOGLOBULIN E
- Code
- 700.0000
- Name
- IMMUNOGLOBULIN E
- Category
- None
- Department
- Send-Out
- Start Date
- Expiration Date
- Synonyms
- IGE, ALLERGEN, TOTAL IGE
- CPT Codes
- 82785
- Site
- SBMF
- Reference Test
- 30099
Specimen Information
- Type
Gold, SST
- Volume
1.0 ml
- Transport Info
Refrigerated
- Fasting Required?
- False
- Patient Instructions
- Reference Range
See report
- Methodology
ImmunoCAP™ Fluorescent Enzyme Immunoassay (FEIA)
Clinical Significance
Diagnose and manage patients with atopic disease such as asthma, hay fever, eczema, and patients with respiratory allergies or parasitic infections.
Immunoglobulin E (IgE) is a class of immunoglobulins important in the mediation of allergic responses. IgE is synthesized primarily within plasma cells found in the mucosa of the respiratory and intestinal tracts and is secreted into the blood. The mechanism of action of the allergic response involves the binding of IgE through its Fc portion to cell surface receptors of mast cells and basophils. After exposure to specific allergens recognized by IgE, the cells release vasoactive amines causing Type I hypersensitivity reactions. IgE levels may be increased in not only allergic disease, but also parasitic infections and bronchopulmonary aspergillosis.