IMMUNOGLOBULIN M

Code
900.2175
Name
IMMUNOGLOBULIN M
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
IgM
CPT Codes
82784
Site
SBMF
Reference Test
28134
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

0-12 months: 0-145 mg/dL
1-3 years: 19-146 mg/dL
4-6 years: 24-210 mg/dL
7-9 years: 32-208 mg/dL
10-11 years: 31-180 mg/dL
12-13 years: 35-239 mg/dL
14-15 years: 15-188 mg/dL
16-19 years: 23-259 mg/dL
20-60 years: 40-230 mg/dL
≥60 years: 30-360 mg/dL

Methodology

Nephelometry

Clinical Significance

Aid in the diagnosis of abnormal protein metabolism and the body's lack of ability to resist infectious agents.

Immunoglobulins are formed by plasma cells as a humoral immune response to contact of the immune system with antigens. The primary reaction after the initial contact is the formation of antibodies of the IgM class followed later by IgG and also IgA antibodies. Quantitative determination of the immunoglobulins can provide important information on the humoral immune status. Decreased serum immunoglobulin concentrations occur in primary immunodeficiency conditions as well as in secondary immune insufficiencies, e.g., in advanced malignant tumors, lymphatic leukemia, multiple myeloma and Waldentrom’s disease. Increased serum immunoglobulins concentrations occur due to polyclonal or ligoclonal Ig proliferation, e.g., in hepatic diseases (hepatitis, liver cirrhosis), acute and chronic infections, autoimmune diseases as well as in the cord blood of neonates with intra-uterine and perinatal infections. Monoclonal immunoglobulin proliferations in the serum are found, e.g. in plasmacytomas, Waldenstrom’s disease and heavy-chain disease. Monoclonal immunoglobulinemia requires detailed differential diagnostic investigations in addition to the quantitative determination.

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