MONO SCREEN

Code
800.0100
Name
MONO SCREEN
Category
None
Department
Serology
Start Date
Expiration Date
Synonyms
Heterophile Antibody; Screen for Infectious Mononucleosis
CPT Codes
86308
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Lavender, EDTA

Volume

1.0 ml

Transport Info

Refrigerated
48 Hour stability

Fasting Required?
False
Patient Instructions

Reference Range

Negative

Methodology

Chromatographic Immunoassay

Clinical Significance

Diagnose infectious mononucleosis.

Heterophile antibody has been rarely associated with disease states other than infectious mononucleosis, such as leukemia, cytomegalovirus, Burkitt's lymphoma, rheumatoid arthritis, and viral hepatitis. A single heterophile antibody titer is considered to have no relation to the severity of the disease, but sequential titer determinations may be useful in following the course of an individual patient. Although most patients (90%) will have a detectable heterophile level within three weeks of infection, occasionally a patient with strong clinical signs of infectious mononucleosis may take as long as three months to develop a detectable level. The heterophile test or mononucleosis slide test is probably the best test for detecting acute Epstein-Barr virus (EBV) infection. Negative results are more common in children. If further testing is desired, collect additional specimens and retest every few days. EBV infection can also be established, especially in "monospot-negative" cases, with the use of EBV IgM-specific serologies.

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