IRON & TIBC

Code
400.4650
Name
IRON & TIBC
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
CPT Codes
83540, 84466
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Iron : 50-150 ug/dL
Transferrin : (M) 180-329 mg/dl, (F) 192-382 mg/dl
TIBC (Calculated) : 250-420 ug/dl
%Sat : 20-55

Methodology

Timed Endpoint

Clinical Significance

Used to diagnosis and treatment of diseases such as iron deficiency anemia, hemochromatosis (a disease associated with widespread deposit in the tissue of the two iron-containing pigments, hemosiderin and hemofuscin, and characterized by pigmentation of skin), and chronic renal disease.

Ingested iron is mainly absorbed in the form of Fe2+ in the duodenum and upper jejunum. The trivalent form and the heme-bound Fe2+-component of iron in food have to be reduced by vitamin C. About 1 mg of iron is assimilated daily. Upon reaching the mucosal cells, Fe2+ ions become bound to transport substances. Before passing into the plasma, these are oxidized by ceruloplasmin to Fe3+ and bound to transferrin in this form. The transport of Fe ions in blood plasma takes place via transferrin-iron complexes. A maximum of 2 Fe2+ ions per protein molecule can be transported. Serum iron is almost completely bound to transferrin.Iron determinations are performed for the diagnosis and monitoring of microcytic anemia (e.g. due to iron metabolism disorders and hemoglobinopathy), macrocytic anemia (e.g. due to vitamin B12 deficiency, folic acid deficiency and drug-induced metabolic disorders of unknown origin) as well as normocytic anemias such as renal anemia (erythropoetin deficiency), hemolytic anemia, hemoglobinopathy, bone marrow disease and toxic bone marrow damage.

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