KAPPA/LAMBDA FREE LIGHT CHAINS, QUANTITATIVE, WITH RATIO, SERUM

Code
900.3729
Name
KAPPA/LAMBDA FREE LIGHT CHAINS, QUANTITATIVE, WITH RATIO, SERUM
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Immunoglobulins, free light chain
CPT Codes
83883 x 2
Site
SBMF
Reference Test
23217
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

0.5 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Free Kappa: Less than or equal to 22.2 mg/L
Free Lambda: Less than or equal to 34.4 mg/L
Ratio Kappa/Lambda: 0.410-1.430

Methodology

Latex-Enhanced, Nephelometric Immunoassay

Clinical Significance

Measurements of free light chains in serum or urine aid in the diagnosis and monitoring of multiple myeloma, lymphocytic neoplasms, Waldenstrom’s macroglobulinemia, amyloidosis, light chain deposition disease, and connective tissue diseases such as systemic lupus erythematosus.

Free light chains (FLC) is a more sensitive test than serum or urine immunofixation (IF) and it is a valuable tool for diagnosing and monitoring patients with secretory and nonsecretory multiple myeloma. Nearly all multiple myeloma patients have increased FLC. Monitoring of FLC provides a quicker indication of response to therapy than monoclonal or total immunoglobulins due to its shorter half-life and the larger clinical ranges of FLC concentrations. 100% of patients with light-chain multiple myeloma, 75% with nonsecretory myeloma, and more than 95% with primary amyloidosis could be diagnosed using FLC.

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