LAMOTRIGINE (LAMICTAL)

Code
900.2375
Name
LAMOTRIGINE (LAMICTAL)
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Lamictal
CPT Codes
80299
Site
SBMF
Reference Test
23109
ATLAS Test Code

Specimen Information

Type

Red, Plain

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

3.0-15.0 µg/mL

Critical High Value: > 20.0 µg/mL

Methodology

Quantitative Enzyme Immunoassay (EIA)

Clinical Significance

Monitoring serum concentration of lamotrigine; assessing compliance; adjusting lamotrigine dose in patients receiving other anticonvulsant drugs which interact pharmacokinetically with lamotrigine.

Lamotrigine (Lamictal) is a phenyltriazine compound that was originally indicated for the adjunctive treatment of partial and generalized seizures, but has recently been used as monotherapy for epilepsy in adults and children. It may also be useful in other neurological conditions such as Parkinson’s disease and motor neuronic disease, Huntington’s chorea, and neuralgia. The exact mode of action of lamotrigine is not fully understood, although it is thought to act by inhibiting the release of excitatory amino acid neurotransmitters, which results in the stabilization of neuronal membranes.Concomitant therapy with other anticonvulsant drugs has a substantial effect on the clearance of lamotrigine. Sodium valproate decreases the rate of metabolism, resulting in reduced lamotrigine clearance, while enzyme inducing drugs such as carbamazepine, phenobarbital and phenytoin accelerate the elimination of lamotrigine.

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