LEPTOSPIRA ANTIBODIES

Code
000.0000
Name
LEPTOSPIRA ANTIBODIES
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
86720
Site
SBMF
Reference Test
44227
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Less than 1:50 = No antibody detected.
1:50 = Borderline positive: patients should be evaluated for clinical correlation with active or recent leptospirosis. Suggest repeat testing in 2-3 weeks.
1:100 = Positive: Suggestive of current or recent leptospirosis.

Methodology

Indirect Hemagglutination

Clinical Significance

Diagnosis of leptospirosis.

Leptospirosis is a zoonotic disease of worldwide prevalence caused by the organism Leptospira biflexa. Although wild mammals (e.g., rodents) serve as a primary natural reservoir, domestic animals (dogs, cattle, swine, horses, etc.) serve as a major source of human infection. Most often transmission is indirect, by human contact with soil, food, or water contaminated by urine from an infected animal. Leptospirosis is probably initiated by entry of the organisms through breaks in the skin or intact mucosa. Leptospiremia follows after an 8-12 day incubation period. Initial clinical symptoms include fever, chills, headache, conjunctivitis, myalgia, and gastrointestinal symptoms. The fever is typically biphasic, initially lasting 4-9 days, followed after a 1-3 day afebrile interval by a secondary febrile phase. Jaundice occurs infrequently in the U.S., although leptospiral meningitis occurs more frequently, accounting for 5-13% of sporadic lymphocytic meningitis cases. The laboratory diagnosis of leptospirosis is complicated by the fact that the organism is fastidious and slow-growing, occasionally requiring weeks to grow. In this context, serology represents an acceptable alternative that may be more timely.

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