LIDOCAINE

Code
000.0000
Name
LIDOCAINE
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Xylocaine
CPT Codes
80176
Site
SBMF
Reference Test
31039
ATLAS Test Code

Specimen Information

Type

Red, Plain

Volume

1.0 ml

Transport Info

Refrigerated
If specimen not sent to SBMF on day collected:
– Serum sample tubes, clot 30 minutes
– Promptly centrifuge 15 minutes
– Immediately transfer serum or plasma to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

Enzyme Multiplied Immunoassay Technique (EMIT)

Clinical Significance

Therapeutic drug monitoring; evaluate toxicity.

Lidocaine, administered intravenously, is a drug effective in the treatment of ventricular arrhythmias. It is also widely used as a local anesthetic where significant systemic absorption can occur. Lidocaine therapeutic effectiveness and toxic side effects show a consistent relationship to the blood concentration rather than the administered dosage. Because of the short half-life and the unpredictability of blood concentrations in patients suffering from cardiac or liver disease, lidocaine should be measured in patients as soon as possible after the blood sample is drawn.Peak serum levels of lidocaine in the range of 1.5 to 5 µg/mL are suggested for optimal therapeutic effectiveness. Elevated concentrations of lidocaine (10 µg/mL) may produce dizziness, tinnitus, drowsiness, paresthesias, twitching, hypotension, bradycardia and double vision. Convulsions and cardiac and respiratory arrest may occur. The metabolism and elimination may be altered by disease states. Patients in cardiac failure under long-term infusions may produce 50% greater plasma concentrations often resulting in central nervous system depression. Patients with chronic liver disease can have reduced lidocaine clearance and may develop toxicity with normal dosage regimens. Prophylactic administration of lidocaine is reported to produce instances of toxicity resulting in symptoms such as dizziness and nausea, to coma or seizures.

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