LITHIUM LEVEL

Code
600.5000
Name
LITHIUM LEVEL
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
Li
CPT Codes
80178
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST or Red, Plain

Volume

1.0 ml

Transport Info

Room Temperature
1 day stability

Refrigerated
7 day stability

Frozen
6 month stability

Fasting Required?
False
Patient Instructions

Reference Range

0.5-1.5 mmol/L

Methodology

Colorimetric

Clinical Significance

Treat manic episodes of manic-depressive illness; evaluate toxicity.

Lithium, administered as lithium carbonate, is used for treatment of manic-depressive illness. Absorption of lithium from the gastrointestinal tract is complete, and the peak plasma concentration is reached in two to four hours after an oral dose. The lithium cation does not bind to protein. Clearance is predominantly by renal excretion.The optimal therapeutic response to lithium has not been related to a specific serum concentration; however, serum lithium concentrations are monitored to ensure patient compliance and to avoid intoxication. A concentration in excess of 1.5 mEq/L in a specimen drawn 12 hours after the dose indicates an increased risk of intoxication. Early symptoms of intoxication include apathy, sluggishness, drowsiness, lethargy, speech difficulties, irregular tremors, myoclonic twitchings, muscle weakness and ataxia. Severe intoxication, characterized by muscle rigidity, hyperactive deep tendon reflexes, and epileptic seizures, is usually, associated with lithium concentrations greater than 2.5 mEq/L.

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