LUPUS CIRCULATING ANTICOAG

Code
900.2600
Name
LUPUS CIRCULATING ANTICOAG
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Lupus anticoagulant detection; Lupus-Like Anticoagulants (LA)
CPT Codes
85610; 85613; 85705; 85730
Site
SBMF
Reference Test
25243
ATLAS Test Code

Specimen Information

Type

Light blue top (3.2% buffered sodium citrate) tube, Platelet-poor plasma (PPP)

Volume

2.0 mL (Two aliquots, 1.0 mL each)

Transport Info

Separate plasma from cells immediately
• Promptly centrifuge 15 minutes
• Carefully transfer plasma portion of sample to separate plastic tube using plastic pipette
• Centrifuge transferred plasma sample again to produce platelet-poor plasma (PPP)
• Use second plastic pipette to carefully transfer PPP sample into 2 plastic aliquot tubes
Frozen

Fasting Required?
False
Patient Instructions

Collect prior to initiation of anticoagulant therapy

Reference Range

Normal: No lupus-like anticoagulants (LA) present
PT: 11-14 seconds
APTT: Less than or equal to 34 seconds
LA1: Less than or equal to 45 seconds
LA2: Less than or equal to 38 seconds
TTI Ratio: Less than or equal to 1.3

Methodology

Clot Detection

Clinical Significance

Determine the presence of lupus-like anticoagulants (LA).

Lupus-like anticoagulants (LA) are immunoglobulins that interfere with one or more of the in vitro phospholipid-dependent steps of coagulation, resulting in prolonged coagulation tests, especially APTT, dRVVT, and TTI. Circulating lupus-like anticoagulants are recognized as a major cause of both venous and arterial thromboembolic events. Often encountered in settings such as recurrent abortion, deep vein thrombosis, and arterial thrombosis, LA may initially present as a prolonged APTT screen.The antiphospholipid protein antibody family includes lupus-like anticoagulants and cardiolipin antibodies, either of which can cause the syndromes described above. Patients may present with lupus-like anticoagulants and cardiolipin antibodies, or with one or the other. The Circulating Anticoagulant Detection test (#25242) for lupus-like anticoagulants plus Cardiolipin IgG and IgM antibodies (#28102 and #28103) are recommended for patients suspected of having a hypercoagulapathy due to an antiphospholipid protein antibody syndrome.

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