LUTEINIZING HORMONE

Code
600.4530
Name
LUTEINIZING HORMONE
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
LH
CPT Codes
83002
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated
14 days stability

Frozen (Freeze Only once)
6 month stability

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

Chemiluminescence

Clinical Significance

The primary clinical use of LH measurement is in clearly defining the hypothalamic-pituitary-gonadal axis. Measurement of serum gonadotropin levels will allow for distinguishing between primary gonadal failure and deficient gonadal stimulation. LH measurement may also be of clinical importance because growth hormone and LH are frequently the first hormones to be affected by pituitary disease. The serum analysis of LH has also been found to be very useful in the diagnosis and treatment of infertility in women.

LH (luteinizing hormone), together with FSH (follicle stimulating hormone), belongs to the gonadotropin family. LH and FSH regulate and stimulate the growth and function of the gonads (ovaries and testes) synergistically. Like FSH, TSH and hCG, LH is a glycoprotein consisting of two subunits (a- and b-chains). This proteohormone, which consists of 121 amino acids and three sugar chains, has a molecular weight of 29,500 D. Within the control system between the hypothalamus, anterior pituitary and ovary, the gonadotropins serve to control the menstrual cycle in women.LH and FSH are released in pulses from the gonadotropic cells of the anterior pituitary and pass via the bloodstream to the ovaries. Here the gonadotropins stimulate the growth and maturation of the follicle and hence the biosynthesis of estrogens and progesterones. The highest LH-concentrations occur during the mid-cycle peak and induce ovulation and formation of the corpus luteum, the principal secretion product of which is progesterone. In the Leydig cells of the testes, LH stimulates the production of testosterone.Determination of the LH concentration is used in the elucidation of dysfunctions within the hypothalamus-pituitary-gonads system. The determination of LH in conjunction with FSH is utilized for the following indications: congenital diseases with chromosome aberrations (e.g. Turner’s syndrome), polycystic ovaries (PCO), clarifying the causes of amenorrhea, menopausal syndrome and suspected Leydig cell insufficiency.

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