LYSOZYME

Code
000.0000
Name
LYSOZYME
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
85549
Site
SBMF
Reference Test
44163
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

All samples: Indicate source on container label and test request form

Fasting Required?
False
Patient Instructions

Reference Range

9-17 µg/mL

Methodology

Quantitative Radial Immunodiffusion (RID)

Clinical Significance

Serum and urine lysozyme levels may be elevated in acute myelomonocytic leukemia (FAB-M4), chronic myelomonocytic leukemia (CMML) and chronic myelocytic leukemia (CML). Increased serum lysozyme activity is present in tuberculosis, sarcoidosis, megaloblastic anemias, acute bacterial infections, ulcerative colitis, regional enteritis and Crohn's disease. Elevated levels of urine and serum lysozyme occur during severe renal insufficiency, renal transplant rejection, urinary tract infections, pyelonephritis, glomerulonephritis and nephrosis.

Lysozyme is an enzyme that hydrolyzes beta 1-4-glucosidic linkages in the mucopolysaccharide cell well of a variety microorganisms. It is present in human serum, urine, tears, seminal fluid, and milk and plays an important role in host defense against infections. Serum and urine lysozyme levels may be elevated in acute myelomonocytic leukemia (FAB-M4), chronic myelomonocytic leukemia (CMML), and chronic myelocytic leukemia (CML). Increased serum lysozyme activity is also present in tuberculosis, sarcoidosis, megaloblastic anemias, acute bacterial infections, ulcerative colitis, and Crohn's disease. Elevated levels of urine and serum lysozyme occur during severe renal insufficiency, renal transplant rejection, urinary tract infections, pyelonephritis, glomerulonephritis, and nephrosis.

Back