MANGANESE, SERUM
- Code
- 000.0000
- Name
- MANGANESE, SERUM
- Category
- None
- Department
- Send-Out
- Start Date
- Expiration Date
- Synonyms
- CPT Codes
- 83785
- Site
- SBMF
- Reference Test
- 44419
Specimen Information
- Type
Dark blue (royal) top tube (trace element-free - serum)
- Volume
2.0 ml
- Transport Info
Centrifuge and "Pour off" serum into metal-free plastic vial
Room temperature- Fasting Required?
- False
- Patient Instructions
- Reference Range
0.0-2.0 µg/L
- Methodology
Quantitative Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)
Clinical Significance
Dietary sources of manganese provide an adequate supply of this essential element; manganese deficiency is not a common occurrence. Experimentally induced manganese deficiencies have been associated with clotting defects, hypocholesterolemia, dermatitis, hypercalcemia, and hyperphosphatemia. Supplemental manganese, however, does not always reverse these changes. Certain disease states have been associated with changes in serum levels. Increased levels are seen in acute hepatitis and myocardial infarction; decreased levels are seen in seizure disorders, maple syrup urine disease, phenylketonuria, and in certain patients with bone and joint malformations. Toxicity results primarily from inhalation of particulate material containing high levels of manganese. Manganese toxicity occurs in miners, foundry workers, welders, pharmaceutical workers, pottery and ceramics makers, varnish manufacturers, and in makers of food additives. This assay contains a digestive step to ensure the complete extraction of manganese.