Cannabinoid Metabolite, Quantitative LC-MS/MS, Urine

Code
900.2668
Name
Cannabinoid Metabolite, Quantitative LC-MS/MS, Urine
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Marijuana by GC/MS; Cannabinoids; Carboxy-THC Confirmation/Quantitation; THC
CPT Codes
82542
Site
SBMF
Reference Test
47144
ATLAS Test Code

Specimen Information

Type

Urine, random

Volume

4.0 ml

Transport Info

Room Temperature. Refrigerated acceptable.

Fasting Required?
False
Patient Instructions

Reference Range

Negative (less than assay limit of detection)

Positive cutoff: 5 ng/mL

Methodology

Liquid Chromatography-Tandem Mass Spectrometry

Clinical Significance

Confirm positive screen results by an alternate, specific method; detect use. Marijuana and its sister drug, hashish, come from the hemp plant Cannabis sativa, which grows throughout the world. These drugs contain at least 61 cannabinoids, of which delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound. Principal routes of administration are inhalation (smoking) and oral ingestion. THC is highly fat soluble and therefore readily stored in fatty tissues, where it may remain in the body for several days or even weeks. It is rapidly transformed by liver enzymes to over 24 metabolites, the primary one being 11-nor-D9-tetrahydrocannabinol-9-carboxylic acid. Approximately 70% of a THC dose is excreted in feces and urine within 72 hours of administration. The concentrations of THC metabolites in urine are influenced by several factors; the amount of THC absorbed in the bloodstream; the frequency of prior use; the timing of urine specimen collection in relation to the last exposure to THC; and the rate of release of stored cannabinoids from fatty tissues. Heavy chronic THC users who stop taking the drug may show positive urine tests for a month or longer. Positive result indicates exposure to the drug and does not necessarily indicate impairment.

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