METANEPHRINES,FRACT,FREE PLSMA

Code
900.2670
Name
METANEPHRINES,FRACT,FREE PLSMA
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Fractionated metanephrines; Free Metanephrine; Normetanephrine
CPT Codes
83835
Site
SBMF
Reference Test
45362
ATLAS Test Code

Specimen Information

Type

Lavender, EDTA

Volume

2.0 ml

Transport Info

Centrifuge and immediately transfer plasma to separate plastic tube
Frozen

CRITICAL FROZEN – Separate samples must be submitted when multiple tests are ordered

Fasting Required?
False
Patient Instructions

Epinephrine and epinephrine-like drugs may affect results, and should be discontinued for at least 72 hours prior specimen collection, if possible
Collect the specimen after the patient has rested for 15 minutes in a supine position

Reference Range

Normetanephrine: 0.0-0.89 nmol/L
Metanephrine: 0.0-0.49 nmol/L

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Clinical Significance

Patients with essential hypertension and plasma concentrations of normetanephrine and metanephrine below 0.9 nmol/L and 0.5 nmol/L, respectively, can be reliably excluded from further testing for the detection of a pheochromocytoma. The majority of patients with pheochromocytoma have a plasma normetanephrine concentration in excess of 2.2 nmol/L and/or metanephrine concentration in excess of 1.1 nmol/L. The presence of increased concentrations of the analytes serves as confirmation for the diagnosis of the tumor.

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