METANEPHRINES,FRACT,FREE PLSMA
- Code
- 900.2670
- Name
- METANEPHRINES,FRACT,FREE PLSMA
- Category
- None
- Department
- Send-Out
- Start Date
- Expiration Date
- Synonyms
- Fractionated metanephrines; Free Metanephrine; Normetanephrine
- CPT Codes
- 83835
- Site
- SBMF
- Reference Test
- 45362
Specimen Information
- Type
Lavender, EDTA
- Volume
2.0 ml
- Transport Info
Centrifuge and immediately transfer plasma to separate plastic tube
FrozenCRITICAL FROZEN – Separate samples must be submitted when multiple tests are ordered
- Fasting Required?
- False
- Patient Instructions
Epinephrine and epinephrine-like drugs may affect results, and should be discontinued for at least 72 hours prior specimen collection, if possible
Collect the specimen after the patient has rested for 15 minutes in a supine position- Reference Range
Normetanephrine: 0.0-0.89 nmol/L
Metanephrine: 0.0-0.49 nmol/L- Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Clinical Significance
Patients with essential hypertension and plasma concentrations of normetanephrine and metanephrine below 0.9 nmol/L and 0.5 nmol/L, respectively, can be reliably excluded from further testing for the detection of a pheochromocytoma. The majority of patients with pheochromocytoma have a plasma normetanephrine concentration in excess of 2.2 nmol/L and/or metanephrine concentration in excess of 1.1 nmol/L. The presence of increased concentrations of the analytes serves as confirmation for the diagnosis of the tumor.