MUMPS VIRUS IGM ANTIBODY

Code
900.2776
Name
MUMPS VIRUS IGM ANTIBODY
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
MUMPS IGM
CPT Codes
86735
Site
SBMF
Reference Test
44255
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Clinical Significance

Mumps is an acute, generally self-limiting, contagious disease of short duration. Bilateral or unilateral parotitis is the most common clinical feature. Secondary involvement of testes, ovaries, central nervous system and, rarely, the pancreas, peripheral nerves, eye, inner ear, and other organs may occur.The incubation period for mumps is 18-21 days. Infections are transmitted by droplet spread from the upper respiratory tract; 25-50% of all infections are silent. Immunity after infection appears to be lifelong; however, silent reinfections may infrequently occur. An attenuated live virus vaccine is available that induces lower levels of measurable antibody than that from natural infection.The test for IgG antibodies is best utilized to determine a patient's immune status to mumps. Seroconversion between acute and convalescent sera is considered strong evidence of current or recent infection. The best evidence for infection is a significant change on two appropriately timed specimens, where both tests are done in the same laboratory at the same time.Appearance of an IgM antibody response normally occurs 7-14 days after the onset of disease. Testing immediately post-exposure is of no value without a later convalescent specimen. While the presence of IgM antibodies suggests current or recent infection, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection or immunization. Such a residual IgM response may be distinguished from early IgM response to infection by testing sera from patients 2-3 weeks later for changing levels of specific IgM antibodies.Assays for IgM are more useful than IgG assays, since cross-reactions have not been observed. Positive IgM mumps antibody suggests infection within the past 2-3 months. For paired sample results, an acute result less than 1:10 and convalescent greater than 1:10, or a fourfold rise in titer, suggests a primary infection with mumps virus unless the individual has recently acquired passive antibody.

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