MYELIN BASIC PROTEIN, CEREBROSPINAL FLUID

Code
900.5750
Name
MYELIN BASIC PROTEIN, CEREBROSPINAL FLUID
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
MBP
CPT Codes
83873
Site
SBMF
Reference Test
44300
ATLAS Test Code

Specimen Information

Type

CSF

Volume

1.0 ml

Transport Info

If CSF is bloody, centrifuge the sample and separate supernatant from cells. Refrigerated. 

NOTE: Hemolysis is associated with falsely-elevated levels of MBP in the cerebrospinal fluid. CSF should be free from contamination with blood, if possible. If all available CSF is bloody, centrifuge the sample and separate supernatant from cells.

Fasting Required?
False
Patient Instructions

Reference Range

0.00‑5.50 ng/mL

Methodology

Quantitative Chemilluminescent Immunoassay

Clinical Significance

Assist in the clinical assessment of the activity of demyelination in multiple sclerosis (MS), following head trauma, and a variety of demyelination disorders. Measurement of myelin basic protein (MBP) in cerebrospinal fluid (CSF) can assist in the clinical assessment of the activity of demyelination in multiple sclerosis (MS), following head trauma, and a variety of demyelination disorders. MBP is usually not found in CSF from patients with inactive demyelinating disorders. Elevated MBP may also be seen in CSF of pediatric patients following convulsions and in infants with respiratory distress syndrome who have developed brain damage.Hemolysis is associated with falsely elevated levels of MBP in the CSF. CSF should be free from contamination with blood, if possible. If all available CSF is bloody, centrifuge the sample and separate supernatant from cells prior to freezing the sample.

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