Phencyclidine (PCP), Quantitative LC-MS/MS, Urine
- Phencyclidine (PCP), Quantitative LC-MS/MS, Urine
- Start Date
- Expiration Date
- PCP, Angel Dust, Sherms
- CPT Codes
- Reference Test
- ATLAS Test Code
- Transport Info
Room Temperature. Refrigerated acceptable.
- Fasting Required?
- Patient Instructions
- Reference Range
Negative (less than assay limit of detection)
Quantitative Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Confirm positive screen results Detect use Phencyclidine (1-phenylcyclohexylpiperidine) is the most commonly abused member of a class of mind-altering drugs known as dissociatives or arylcyclohexylamines. PCP and its analogs, easily and inexpensively manufactured in clandestine labs, are generally mixed with marijuana or tobacco and smoked. PCP is lipophilic and stored by the body in brain and adipose tissue for considerable periods. The half-life of PCP has been estimated at 7 to 50 hours. Metabolism occurs mainly in the liver through oxidative hydroxylation. PCP is excreted primarily as unchanged drug and inactive conjugates. Complete excretion of the drug usually occurs within 72 hours of administration; however, urine samples may remain positive for as long as two weeks after administration. Renal clearance of PCP is increased markedly with urinary acidification. Plasma and urine concentrations of the drug do not appear to relate to the degree of intoxication. Positive result indicates exposure to drug and does not necessarily indicate impairment.