PHENCYCLIDINE SCREEN BY EIA, URINE

Code
000.0000
Name
PHENCYCLIDINE SCREEN BY EIA, URINE
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
PCP; Angel Dust
CPT Codes
80101
Site
SBMF
Reference Test
29086
ATLAS Test Code

Specimen Information

Type

Urine, random

Volume

5.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Results of this assay distinguish positive (greater than or equal to 25 ng/mL) from negative samples only. The amount of drug detected in a positive sample cannot be estimated.

Methodology

Enzyme Immunoassay (EIA)

Clinical Significance

Used as an aid in the diagnosis and treatment of phencyclidine use or overdose
Phencyclidine (1-phenylcyclohexylpiperidine) is the most commonly abused member of a class of mind-altering drugs known as dissociatives or arylcyclohexylamines. Once marketed as intravenous anesthetic for humans, the drug was classified as illegal in 1967 under the Comprehensive Drug Abuse Prevention and Control Act.PCP and its analogs, easily and inexpensively manufactured in clandestine labs, are generally mixed with marijuana or tobacco and smoked. Other routes of administration include nasal insufflatin, oral ingestion, and intravenous injection. PCP intake can cause lethargy, sedation, disorientation, and agitation; in higher doses, hallucinations, psychoses, seizures, and coma.PCP is lipophilic and stored by the body in brain and adipose tissue for considerable periods. The half-life of PCP has been estimated at 7 to 50 hours. Metabolism occurs mainly in the liver through oxidative hydroxylation. PCP is excreted primarily as unchanged drug and inactive conjugates. Complete excretion of the drug usually occurs within 72 hours of administration; however, urine samples may remain positive for as long as 2 weeks after markedly with urinary acidification. Plasma and urine concentrations of the drug do not appear to relate to the degree of intoxication.This assay is appropriate for testing under the Substance Abuse and Mental Health Services Administration, (SAMHSA, formerly National Institute on Drug Abuse) guidelines, which recommend a cutoff level of 25 ng/mL.

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