POLIOVIRUS ANTIBODIES

Code
000.0000
Name
POLIOVIRUS ANTIBODIES
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
86658 x 3
Site
SBMF
Reference Test
44095
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Less than 1:10: No detectable poliovirus antibodies
1:10 or greater: Antibody to poliovirus detected, which may represent prior immunization or current or past infection
The presence of neutralizing antibodies against poliovirus implies immunity. The serum neutralization test is serotype specific. Antibodies against one type does not indicate immunity against other types.
Reference Interval applies to Poliovirus Antibody Types 1, 2 and 3.

Methodology

Serum Neutralization Assay

Clinical Significance

Poliovirus types 1, 2, and 3 are the cause of paralytic poliomyelitis (both spinal and bulbar). Viral isolation is the preferred method of laboratory diagnosis. In cases of central nervous system disease, amplification techniques are the most sensitive. In the absence of this capability, serology can be used to support a clinical diagnosis of polio. Cerebrospinal fluid can be tested. However, the clinical significance of and the criteria for interpretation of results have not been established. The presence of poliovirus antibodies may represent prior immunization or acute infection. The clinical significance of and the criteria for interpretation of results may require consultation with an Infectious Diseases Specialist. In immunized individuals, the significance of a low antibody titer to poliovirus 3 (the least immunogenic vaccine serotype) is unclear.

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