- POLIOVIRUS ANTIBODIES
- Start Date
- Expiration Date
- CPT Codes
- 86658 x 3
- Reference Test
- Transport Info
Centrifuge and immediately transfer serum to separate plastic tube
- Fasting Required?
- Patient Instructions
- Reference Range
Less than 1:10: No detectable poliovirus antibodies
1:10 or greater: Antibody to poliovirus detected, which may represent prior immunization or current or past infection
The presence of neutralizing antibodies against poliovirus implies immunity. The serum neutralization test is serotype specific. Antibodies against one type does not indicate immunity against other types.
Reference Interval applies to Poliovirus Antibody Types 1, 2 and 3.
Serum Neutralization Assay
Poliovirus types 1, 2, and 3 are the cause of paralytic poliomyelitis (both spinal and bulbar). Viral isolation is the preferred method of laboratory diagnosis. In cases of central nervous system disease, amplification techniques are the most sensitive. In the absence of this capability, serology can be used to support a clinical diagnosis of polio. Cerebrospinal fluid can be tested. However, the clinical significance of and the criteria for interpretation of results have not been established. The presence of poliovirus antibodies may represent prior immunization or acute infection. The clinical significance of and the criteria for interpretation of results may require consultation with an Infectious Diseases Specialist. In immunized individuals, the significance of a low antibody titer to poliovirus 3 (the least immunogenic vaccine serotype) is unclear.