PORPHYRINS, FECES

Code
000.0000
Name
PORPHYRINS, FECES
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
84126
Site
SBMF
Reference Test
44457
ATLAS Test Code

Specimen Information

Type

Feces

Volume

5.0 g

Transport Info

CRITICAL FROZEN – Separate samples must be submitted when multiple tests are ordered
Freeze sample immediately after collection
Wrap in foil ASAP to protect from light

Fasting Required?
False
Patient Instructions

Reference Range

Coproporphyrin
0-45 nmol/g dry weight

Protoporphyrin
0-100 nmol/g dry weight

Methodology

Quantitative High Performance Liquid Chromatography (HPLC)

Clinical Significance

Fecal porphyrins are elevated in disorders such as erythropoietic protoporphyria, hereditary coproporphyria, and variegate porphyria. Coproporphyrins can be elevated in a variety of acquired conditions, including by diet or liver disease. Fecal porphyrins will be normal in acute intermittent porphyria. Bacterial modification of fecal porphyrins is extensive, and other specimens (urine, serum, and duodenal aspirates) should be considered. Certain porphyrin intermediates (coproporphyrin, protoporphyrin) are fat soluble and will be excreted in the bile and stool. Coproporphyrin is somewhat water soluble and appears in the urine as well.

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