PROGESTERONE

Code
600.4590
Name
PROGESTERONE
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
PROG
CPT Codes
84144
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated
48 hour stability

Frozen (Freeze only once)
6 months

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

Chemiluminescence

Clinical Significance

Ovarian function test; establish the presence of a functioning corpus luteum or luteal cell function; confirm basal body temperature measurements for the occurrence of ovulation; obtain an indication of the day of ovulation; evaluate the functional state of the corpus luteum in infertility patients; assess placental function during pregnancy.

The gestagen progesterone is a steroid hormone having a molecular weight of 314.5 daltons. Progesterone is mainly formed in the cells of the corpus luteum and during pregnancy in the placenta.The progesterone concentration correlates with the development and regression of the corpus luteum. Whereas progesterone is barely detectable in the follicular phase of the female cycle, a rise in the progesterone level is observed one day prior to ovulation. Increased progesterone synthesis occurs during the luteal phase. In the second half of the cycle pregnanediol is execreted in urine as the main degradation product of progesterone.Progesterone brings about the conversion of the uterine mucosa into a tissue rich in glands (secretion phase), in order to prepare for the intrauterine implantation of the fertilized ovum. During pregnancy, progesterone inhibits the contraction of the myometrium. In the mammary gland, progesterone (together with estrogens) promotes the proliferation and secretion disposition of the alveoli.The determination of progesterone is utilized in fertility diagnosis for the detection of ovulation and assessment of the luteal phase.

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