RISPERIDONE AND METABOLITE QUANTITATION

Code
000.0000
Name
RISPERIDONE AND METABOLITE QUANTITATION
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Risperdal®, Risperidone Metabolite, Total Active Moiety
CPT Codes
80299
Site
SBMF
Reference Test
44157
ATLAS Test Code

Specimen Information

Type

Red, Plain

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

Clinical Significance

Therapeutic Drug Monitoring/Antipsychotic (Neuroleptic)

Risperidone (Risperdal) is a relatively unique antipsychotic drug of the benzisoxazole class that is used in the management of the manifestations of schizophrenia. Its activity is thought to be mediated through the antagonism of a combination of dopamine type 2 (D2) and serotonin type 2 (5HT2) receptors. The efficacy of antipsychotic activity was established in short-term (6-8 weeks) controlled trials. A physician who counsels patients to use risperidone for longer periods of time is advised to periodically re-evaluate the long-term usefulness for each individual patient. THERAPEUTIC MONITORING: Among other products, biotransformation in the liver produces 9-hydroxyrisperidone, which is of the same pharmacological activity and intensity as parent risperidone. For this reason, it is important to add the measurement of risperidone and 9-hydroxyrisperidone together when monitoring the antischizophrenic therapy of risperidone administration. The apparent half-life of risperidone is 3 hours, and for 9-hydroxyrisperidone it is 21 hours. Steady state for risperidone is usually reached in one day and in 5-6 days for the metabolite. The concentrations of risperidone plus 9-hydroxyrisperidone are dose-proportional with the dosing range of 1-16 mg per day. Following oral administration, mean peak plasma concentrations of risperidone and 9- hydroxyrisperidone occur at ca. 1 and 3 hours, respectively.

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