STRIATED MUSCLE IGG ANTIBODY WITH REFLEX TO TITER

Code
000.0000
Name
STRIATED MUSCLE IGG ANTIBODY WITH REFLEX TO TITER
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Skeletal Muscle IgG Ab
CPT Codes
86255; If reflexed, add: 86256
Site
SBMF
Reference Test
44486
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Screen: < 1:40 No antibody detected.
Titer: < 1:40 No antibody detected.

Methodology

Semi-Quantitative Indirect Fluorescent Antibody (IFA)

Clinical Significance

Demonstration of striated muscle antibody may be of use in the serologic assessment of certain muscular diseases.

The presence of a skeletal muscle antibody (>/=1:80) in conjunction with a positive acetylcholine receptor site assay is helpful in the confirmatory diagnosis of myasthenia gravis (MG), especially in patients with MG and thymoma. The absence of this antibody argues against the presence of thymoma in patients with MG. Similar antibodies can be found to cardiac muscle. Patients with rheumatic fever, myocardial infarction, and a variety of postcardiotomy states may demonstrate antibodies detected using both skeletal and cardiac tissue.

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