T3 TOTAL

Code
600.3537
Name
T3 TOTAL
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
Triiodothyronine; Total; Total T3
CPT Codes
84480
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated
7 day stability

Frozen (Freeze Only once)
1 month stability

Fasting Required?
False
Patient Instructions

Reference Range

0.87-1.78 ng/mL

Methodology

Chemiluminescence

Clinical Significance

Utilized in the diagnosis of T3-hyperthyroidism, the detection of early stages of hyperthyroidism and for indicating a diagnosis of thyrotoxicosis factitia.
Triiodothyronine (T3) is the hormone principally responsible for the development of the effects of the thyroid hormones on the various target organs. T3 (3, 5, 3’-triiodothyronine) is mainly formed extrathyroidally, particularly in the liver, by enzymatic 5’-deiodination of T4. Accordingly, the T3 concentration in serum is more a reflection of the functional state of the peripheral tissue than the secretory performance of the thyroid gland. A reduction in the conversion of T4 to T3 results in a fall in the T3 concentration. It occurs under the influence of medicaments such as propanolol, glucocorticoids or amiodarone and in severe non-thyroidal illness (NTI), and is referred to as the “low T3 syndrome.” As with T4, over 99% of T3 is bound to transport proteins. However, the affinity of T3 to them is around 10-fold lower.The determination of T3 is utilized in the diagnosis of T3-hyperthyroidism, the detection of early stages of hyperthyroidism and for indicating a diagnosis of thyrotoxicosis factitia.

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