THROMBIN CLOTTING TIME

Code
000.0000
Name
THROMBIN CLOTTING TIME
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
85670
Site
SBMF
Reference Test
25235
ATLAS Test Code

Specimen Information

Type

Light blue top (3.2% buffered sodium citrate) tube, Platelet-poor plasma (PPP)

Volume

2.0 mL (Two aliquots, 1.0 mL each)

Transport Info

Separate plasma from cells immediately
• Promptly centrifuge 15 minutes
• Carefully transfer plasma portion of sample to separate plastic tube using plastic pipette
• Centrifuge transferred plasma sample again to produce platelet-poor plasma (PPP)
• Use second plastic pipette to carefully transfer PPP sample into plastic aliquot tubes
Frozen

Fasting Required?
False
Patient Instructions

Collect prior to initiation of anticoagulant therapy

Reference Range

Less than 21 seconds

Methodology

Clot Detection

Clinical Significance

Used in determination of severe hypofibrinogenemia, dysfibrinogenemia, and presence of heparin-like anticoagulant. Also useful in diagnosis and monitoring of disseminated intravascular coagulation (DIC) and fibrinolysis.

The thrombin clotting time (TCT) procedure is a rapid test method that is useful in the evaluation of hemostasis and thrombosis. TCT is a screening test for presence of sufficient amount of functional (clottable) fibrinogen. A standard concentration of thrombin is added to undiluted plasma and the clotting time is measured. TCT is used in determination of severe hypofibrinogenemia, dysfibrinogenemia, and presence of heparin-like anticoagulants. It is also useful in diagnosis and monitoring of disseminated intravascular coagulation (DIC) and fibrinolysis.The test is based on conversion of functional fibrinogen to fibrin upon addition of thrombin to plasma.The determination of the thrombin time using BC Thrombin Reagent is suitable for: 1) monitoring heparin therapy using unfractionated heparin; 2) fibrinolysis therapy; 3) screening for disorders of fibrin formation, and 4) in cases of suspected severe fibrinogen deficiency states, and differentiating between a heparin-induced prolongation of the thrombin time and fibrin formation disorders.

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