THYROID STIMULATING HORMONE

Code
500.5500
Name
THYROID STIMULATING HORMONE
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
TSH; fTSH; fast TSH
CPT Codes
84443
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

2.0 ml

Transport Info

Refrigerated
7 day stability

Frozen (Freeze Only once)
1 month stability

Fasting Required?
False
Patient Instructions

Reference Range

0.32-5.0 uIu/ml

Methodology

Chemiluminescence

Clinical Significance

TSH serves as the initial test in thyroid diagnostics.

Thyroid-stimulating hormone (TSH, thyrotropin) is a glycoprotein having a molecular weight of approximately. 30,000 daltons and consisting of two subunits. The beta-subunit carries the TSH-specific immunological and biological information, whereas the alpha-chain carries species-specific information and has an identical amino acid sequence to the alpha-chains of LH, FSH and hCG. TSH is formed in specific basophil cells of the anterior pituitary and is subject to a circardian secretion sequence. The hypophyseal release of TSH (thyrotropic hormone) is the central regulating mechanism for the biological action of thyroid hormones. TSH has a stimulating action in all stages of thyroid hormone formation and secretion; it also has a proliferative effect. The determination of TSH serves as the initial test in thyroid diagnostics. Even very slight changes in the concentrations of the free thyroid hormones bring about much greater opposite changes in the TSH level. Accordingly, TSH is a very sensitive and specific parameter for assessing thyroid function and is particularly suitable for early detection or exclusion of disorders in the central regulating circuit between the hypothalamus, pituitary and thyroid.

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