HEPARIN-ASSOCIATED ANTIBODY, PF4

Code
900.0030
Name
HEPARIN-ASSOCIATED ANTIBODY, PF4
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
HIT; Heparin Induced Thrombocytopenia; PF4
CPT Codes
86022
Site
SBMF
Reference Test
28144
ATLAS Test Code

Specimen Information

Type

Red, plain

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Anti-HEPARIN-PF4: Less than 0.40 O.D.

Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Clinical Significance

Heparin is one of the most common causes of drug-induced thrombocytopenia. Heparin-induced thrombocytopenia (HIT) is subdivided into two groups. Type I is attributed to a direct interaction between heparin and platelets. Type I HIT is generally considered a benign condition and is not antibody-mediated. Type II HIT is of immunological origin and characterized by immune-mediated activation and clearance of platelets. It occurs 5-14 days after heparin exposure in 1-3% of patients and is associated with thrombosis. In untreated HIT, progression to thrombosis occurs in up to 50% of patients. Venous thromboembolism accounts for the majority of the thrombotic events but arterial thrombosis may also occur.

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