BETA-HYDROXYBUTYRIC ACID

Code
000.0000
Name
BETA-HYDROXYBUTYRIC ACID
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
ß-Hydroxybutyric Acid
CPT Codes
82010
Site
SBMF
Reference Test
29184
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

0.02-0.27 mMol/L

Methodology

Quantitative Enzymatic Assay

Clinical Significance

Ketosis is the accumulation in the body of the ketone bodies: acetone, acetoacetate, and beta-hydroxybutyric acid (ß-HB). It is a common feature in acutely ill patients, such as those suffering from starvation, acute alcohol abuse, or diabetes mellitus. Ketosis may result in severe, life-threatening metabolic acidosis. The presence and degree of ketosis can be determined by measuring blood levels of ß-HB. Ordinarily, ß-HB is the ketone body present in the greatest amount in serum (approximately 75%). During ketosis, the percentage of ß-HB increases even more, making it a more reliable index of ketoacidosis than the other two ketone bodies. In diabetes, the measurement of ß-HB, as well as serum glucose, is useful for assessment of the severity of diabetic coma. It also helps exclude hyperosmolar non-ketotic diabetic coma. Moreover, insulin requirements are often based on the extent of the existing hyperketonemia shown by the blood levels of ß-HB.

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