BISMUTH, BLOOD

Code
000.0000
Name
BISMUTH, BLOOD
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Bi
CPT Codes
83018
Site
SBMF
Reference Test
44545
ATLAS Test Code

Specimen Information

Type

Dark blue (royal) top (trace metal-free - EDTA) tube, WHOLE BLOOD

Volume

7.0 ml

Transport Info

Room Temperature

Fasting Required?
False
Patient Instructions

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician

Reference Range

0-5 µg/L

Methodology

Quantitative Inductively Coupled Plasma/Mass Spectrometry (ICP/MS)

Clinical Significance

Medical uses of bismuth compounds are largely responsible for excessive exposure to bismuth, one of the rarest of the trace elements. Bismuth-containing formulations are used as antiseptics, astringents, and antacids, as well as for treatment of duodenal ulcers and peptic diseases and for eradication of Helicobacter pylori infections. Bismuth toxicity from workplace exposure has not been documented, although toxicity does occur from over-medication with bismuth- containing drugs. Renal damage is the major effect, but encephalopathy and peripheral neuropathy are also frequently noted. Absorbed bismuth is mainly excreted in the urine. Bismuth levels in blood and urine increase significantly when treatments include administration of bismuth-containing compounds. Blood concentrations equal to or less than 50 µg/L have been designated as safe; levels >100 µg/L as alarm levels. Urine levels may increase manyfold at the end of treatment.

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