SOLUBLE TRANSFERRIN RECEPTOR

Code
900.3958
Name
SOLUBLE TRANSFERRIN RECEPTOR
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
sTfR
CPT Codes
84238
Site
SBMF
Reference Test
44004
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Centrifuge and immediately transfer serum to separate plastic tube
Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Male - 18 years & older: 2.2-5.0 mg/L
Female - 18 years & older: 1.9-4.4 mg/L

Methodology

Quantitative Immunoturbidimetric Assay

Clinical Significance

May be useful in combination with other tests of iron status in differentiating iron deficiency anemia from anemia of chronic disease.

The transferrin receptor (TfR) is expressed on the surface of human cells that require iron and acts as an iron transporting molecule. TfR binds plasma diferric transferrin and internalizes the Tfr-transferrin complex, where transferrin loses its iron to the cytosol. The receptor-bound transferrin recycles to the cell surface, loses the bound apotransferrin, and is able to bind another diferric transferrin. The expression of TfR depends on the concentration of Fe in the cellular cytoplasm. The concentration of soluble TfR (sTfR) has been reported to be proportional to the total amount of cell-associated TfR. The concentration of serum sTfR changes under two conditions: 1. Serum sTfR is increased in iron deficiency. 2. Serum sTfR is increased in conditions of high turnover (i.e., hemolytic anemia).

Back

Patients & Visitors

Make a First Appointment Maternity Pre-Registration Make a Donation Recognize a Sarah Bush Lincoln Employee