KAPPA/LAMBDA FREE LIGHT CHAINS, QUANTITATIVE, WITH RATIO, URINE, 24-HOUR

Code
000.0000
Name
KAPPA/LAMBDA FREE LIGHT CHAINS, QUANTITATIVE, WITH RATIO, URINE, 24-HOUR
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
83883 x 2
Site
SBMF
Reference Test
23219
ATLAS Test Code

Specimen Information

Type

24 HR Urine Container

Volume

2.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Free Kappa: 1.35-24.19 mg/L
Free Lambda: 0.24-6.66 mg/L
Ratio Kappa/Lambda: 2.040-10.370

Methodology

Latex-Enhanced, Nephelometric Immunoassay

Clinical Significance

Measurements of free light chains in serum or urine aid in the diagnosis and monitoring of multiple myeloma, lymphocytic neoplasms, Waldenstrom’s macroglobulinemia, amyloidosis, light chain deposition disease, and connective tissue diseases such as systemic lupus erythematosus.

Free light chains (FLC) is a more sensitive test than serum or urine immunofixation (IF) and it is a valuable tool for diagnosing and monitoring patients with secretory and nonsecretory multiple myeloma. Nearly all multiple myeloma patients have increased FLC. Monitoring of FLC provides a quicker indication of response to therapy than monoclonal or total immunoglobulins due to its shorter half-life and the larger clinical ranges of FLC concentrations. 100% of patients with light-chain multiple myeloma, 75% with nonsecretory myeloma, and more than 95% with primary amyloidosis could be diagnosed using FLC.

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