- LAMOTRIGINE (LAMICTAL)
- Start Date
- Expiration Date
- CPT Codes
- Reference Test
- Transport Info
Centrifuge and immediately transfer serum to separate plastic tube
- Fasting Required?
- Patient Instructions
- Reference Range
Critical High Value: > 20.0 µg/mL
Quantitative Enzyme Immunoassay (EIA)
Monitoring serum concentration of lamotrigine; assessing compliance; adjusting lamotrigine dose in patients receiving other anticonvulsant drugs which interact pharmacokinetically with lamotrigine.
Lamotrigine (Lamictal) is a phenyltriazine compound that was originally indicated for the adjunctive treatment of partial and generalized seizures, but has recently been used as monotherapy for epilepsy in adults and children. It may also be useful in other neurological conditions such as Parkinson’s disease and motor neuronic disease, Huntington’s chorea, and neuralgia. The exact mode of action of lamotrigine is not fully understood, although it is thought to act by inhibiting the release of excitatory amino acid neurotransmitters, which results in the stabilization of neuronal membranes.Concomitant therapy with other anticonvulsant drugs has a substantial effect on the clearance of lamotrigine. Sodium valproate decreases the rate of metabolism, resulting in reduced lamotrigine clearance, while enzyme inducing drugs such as carbamazepine, phenobarbital and phenytoin accelerate the elimination of lamotrigine.