LDH

Code
400.4300
Name
LDH
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
CPT Codes
83615
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Room Temperature
7 day stability

Refrigerated
4 day stability

Frozen
6 week stability

Fasting Required?
False
Patient Instructions

Reference Range

80-180 IU/L

Methodology

Enzymatic Rate

Clinical Significance

Elevations are found in cardiac disease including myocardial infarction, liver diseases including cirrhosis and alcoholism, neoplasia, infectious mononucleosis, hypothyroidism, lung diseases, diseases of central nervous system, infections, inflammatory states, hemolytic anemia, megaloblastic anemia including pernicious anemia, muscular damage, muscular dystrophy, collagen disease • High levels occur with renal infarct, without significant elevation of AST, ALT, or alkaline phosphatase.

LD is found in all cells of the body, with extremely high levels found in specific tissues such as the heart, liver, kidneys, skeletal muscle, and erythrocytes. Therefore, increased levels seen in the serum can be directly related to damage of one of these tissues. Tissue levels of LD are 500-fold higher than whole blood levels. Total LD can be used to differentiate myocardial infarction, in which total LD is three to four times normal, from angina and periocarditis, in which LD levels are normal.

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