MANGANESE, SERUM

Code
000.0000
Name
MANGANESE, SERUM
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
CPT Codes
83785
Site
SBMF
Reference Test
44419
ATLAS Test Code

Specimen Information

Type

Dark blue (royal) top tube (trace element-free - serum)

Volume

2.0 ml

Transport Info

Centrifuge and "Pour off" serum into metal-free plastic vial
Room temperature

Fasting Required?
False
Patient Instructions

Reference Range

0.0-2.0 µg/L

Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Clinical Significance

Dietary sources of manganese provide an adequate supply of this essential element; manganese deficiency is not a common occurrence. Experimentally induced manganese deficiencies have been associated with clotting defects, hypocholesterolemia, dermatitis, hypercalcemia, and hyperphosphatemia. Supplemental manganese, however, does not always reverse these changes. Certain disease states have been associated with changes in serum levels. Increased levels are seen in acute hepatitis and myocardial infarction; decreased levels are seen in seizure disorders, maple syrup urine disease, phenylketonuria, and in certain patients with bone and joint malformations. Toxicity results primarily from inhalation of particulate material containing high levels of manganese. Manganese toxicity occurs in miners, foundry workers, welders, pharmaceutical workers, pottery and ceramics makers, varnish manufacturers, and in makers of food additives. This assay contains a digestive step to ensure the complete extraction of manganese.

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