METHAQUALONE SCREEN BY EIA, URINE

Code
000.0000
Name
METHAQUALONE SCREEN BY EIA, URINE
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
Lude; Quaalude; Sopor
CPT Codes
80101
Site
SBMF
Reference Test
31255
ATLAS Test Code

Specimen Information

Type

Urine, random

Volume

5.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

Negative (screening cut-off is 300 ng/mL)

Methodology

Enzyme Immunoassay (EIA) [Moderate complexity]

Clinical Significance

Methaqualone is a sedative-hypnotic that is usually taken orally. Methaqualone is extensively metabolized and excreted in the urine in the form of a number of metabolites (up to 12 metabolites have been identified). Methaqualone is extensively metabolized principally by hydroxylation at virtually every position on the molecule. Principle metabolites are hydroxymethaqualones, o-glucuronides and methaqualone N-oxide. 40-50% of the dose is excreted within 72 hours with less than 2% as unchanged drug. In 24 hours about 10% is excreted as conjugated 4’-hydroxy metabolites, 7% as N-oxide, 5% as conjugated 2’-hydroxy methyl derivative, and about 3% each the conjugated 2’-hydroxy methyl, 3’-hydroxy and 6’-hydroxy metabolites. Methaqualone and its metabolites collect in fat with a large volume of distribution. Methaqualone and its metabolites have been detected in urine for up to two weeks in concentrations of 0.5-1.0 µg/mL after a single 300 mg dose. Methaqualone was formerly a common drug of abuse (“sopors,” “ludes”, Quaaludes). Presently, it is not legally manufactured in the United States. The assay detects methaqualone, methaqualone metabolites, and the pharmaceutically similar drug, mecloqualone, in human urine. Positive results for samples containing other compounds structurally unrelated to methaqualone have not been observed.

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