RUBELLA IGG ANTIBODY

Code
800.6220
Name
RUBELLA IGG ANTIBODY
Category
None
Department
Chemistry
Start Date
Expiration Date
Synonyms
German Measles IgG Antibody
CPT Codes
86762
Site
Main Lab
Reference Test
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Room Temperature
3 day stability

Refrigerated
3 day stability

Frozen
3 month stability

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

Chemiluminescence

Clinical Significance

Rubella, also known as German measles, occurs throughout the world. The prodromal stage includes malaise and a low-grade fever, followed by characteristic lymphadenitis and finally a macular or maculopapular rash. While rubella is primarily an infection of children, rubella infections during pregnancy can result in congenital infections with disastrous consequences. Birth defects, such as deafness and/or congenital heart defects are the most common. Multiple defects such as mental retardation, cataracts and hepatosplenomegaly may also occur and contribute to death of the infant in the first year of life. Infants with congenital infections may secrete virus for up to two years. Contact with these children poses a risk to susceptible pregnant women. Clinical symptoms of rubella infection are frequently mild or nonspecific, making the infection difficult to diagnose clinically. For these reasons, pregnant women with an undiagnosed illness with rash should be evaluated for the possibility of an acute, primary rubella infection. While the virus can be cultured in vitro, serology remains the principal means for establishing a clinical diagnosis of acquired rubella and congenital infections. As two-thirds of defects are not apparent at birth, it is recommended that children exposed in utero be monitored for clinical and serological status until school age. A rubella vaccine, introduced in 1969, has significantly lowered the incidence of both acute disease and congenital rubella syndrome. However, as the vaccination program may vary with geographical location and as the level of immunity provided by vaccination is not always adequate, pregnant women and women of child-bearing age are routinely screened for immune status. The presence of rubella antibodies indicates a previous vaccination or infection and is indicative of presumptive immunity. Patients suspected of having primary, acute rubella infection should be tested for the presence of IgM antibodies.

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