SSB(LA) IGG ANTIBODY

Code
900.0610
Name
SSB(LA) IGG ANTIBODY
Category
None
Department
Send-Out
Start Date
Expiration Date
Synonyms
ENA Antibody; La Antibody
CPT Codes
86235
Site
SBMF
Reference Test
28330
ATLAS Test Code

Specimen Information

Type

Gold, SST

Volume

1.0 ml

Transport Info

Refrigerated

Fasting Required?
False
Patient Instructions

Reference Range

See Report

Methodology

Multiplex Flow Immunoassay

Clinical Significance

Aid in establishing the diagnosis of Sjogren’s Syndrome and some forms of lupus.

The presence of SSA (Ro) (52 and 60 kDa) and SSB (La) IgG antibodies can be seen in patients with autoimmune diseases, particularly patients with Sjogren’s Syndrome and Lupus Erythematosis (LE). SSA and SSB are both extractable nuclear antigens (ENA) that are useful markers for these autoimmune diseases. In addition to being found in some patients with Sjogren’s Syndrome and LE, SSA antibody can also be seen in patients with rheumatoid arthritis and in infants with neonatal LE. It is important to note that testing for SSA and SSB antibodies is not of use for patients who do not have demonstrable antinuclear antibodies (ANA-negative patients). Autoantibodies against ENAs occur in a large number of patients with systemic rheumatic diseases. These diseases are characterized by the presence of one or more ENA autoantibody as follows: SSA (Ro): Sjögren’s syndrome (40-70%), SLE (25-30%), Neonatal lupus. SSB (La): Sjögren’s syndrome (50-60%), SLE (15%), Systemic sclerosis, Neonatal lupus.

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